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Olivier Martin

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Rozenn Le Guyader

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Thierry Balliau

portrait de Christine DillmannChristine DILLMANN


Génétique Quantitative et Évolution - Le Moulon
INRA, Université Paris-Sud, CNRS, AgroParisTech
Ferme du Moulon
91190 Gif sur Yvette, France


Professor at the Université Paris-Sud
Head of  BASE team
Deputy director of the lab Quantitative Genetics & Evolution - Le Moulon

Research interests

I am interested in understanding the causes of phenotypic variation within populations, and the (co)evolution of genetic polymorphism and phenotypic variation.

> Team BASE


> Statistical modelling

> Mathematics and Biology: with my colleagues Judith Legrand and Domenica Mannicacci, we coordinate the teaching of biomathematics for licence and master Biology students at the Université Paris-Sud, in collaboration with the department of Mathematics.
Preliminary version of the course on biostatistics for Master1 students.

> Quantitative genetics
Course on quantitative genetics data on human height from the biology students of university Paris-Sud
Data on human height from the biology students of University Paris-Sud.

Research and University management

Member of the Council of the Biology department, Université Paris-Sud (2012-2016)

Actively involved in the evaluation of research: CCSU, Université  Paris-Sud ; CSS GVA (researchers)  and CEI (engineers) INRA.


> From 2008 to 2015

Sabarly V., Aubron C., Glodt J., Balliau T., Langella O., Chevret D., Rigal O., Bourgais A., Picard B., de Vienne D., Denamur E., Bouvet O., Dillmann C. (2015) Interactions between genotype and environment drive the metabolic phenotype within Escherichia coli isolates. Environ Microbiol,

Ressayre A., Glemin S., Montalent P., Serre-Giardi L., Dillmann C., Joets J. (2015) Introns Structure Patterns of Variation in Nucleotide Composition in Arabidopsis thaliana and Rice Protein-Coding Genes. Genome Biol Evol, 7 (10) 2913-28.

Durand E., Tenaillon M. I., Raffoux X., Thepot S., Falque M., Jamin P., Bourgais A., Ressayre A., Dillmann C. (2015) Dearth of polymorphism associated with a sustained response to selection for flowering time in maize. BMC Evol Biol, 15 103.

da Silva T., Albertin W., Dillmann C., Bely M., la Guerche S., Giraud C., Huet S., Sicard D., Masneuf-Pomarede I., de Vienne D., Marullo P. (2015) Hybridization within Saccharomyces Genus Results in Homoeostasis and Phenotypic Novelty in Winemaking Conditions. PLoS One, 10 (5) e0123834.

Blein-Nicolas M., Albertin W., da Silva T., Valot B., Balliau T., Masneuf-Pomarede I., Bely M., Marullo P., Sicard D., Dillmann C., de Vienne D., Zivy M. (2015) A Systems Approach to Elucidate Heterosis of Protein Abundances in Yeast. Mol Cell Proteomics, 14 (8) 2056-71.

Spor A., Kvitek D. J., Nidelet T., Martin J., Legrand J., Dillmann C., Bourgais A., de Vienne D., Sherlock G., Sicard D. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in yeast. Evolution, 68 (3) 772-90.

Blein-Nicolas M., Albertin W., Valot B., Marullo P., Sicard D., Giraud C., Huet S., Bourgais A., Dillmann C., de Vienne D., Zivy M. (2013) Yeast proteome variations reveal different adaptive responses to grape must fermentation. Mol Biol Evol, 30 (6) 1368-83.

Albertin W., Marullo P., Bely M., Aigle M., Bourgais A., Langella O., Balliau T., Chevret D., Valot B., da Silva T., Dillmann C., de Vienne D., Sicard D. (2013) Linking post-translational modifications and variation of phenotypic traits. Mol Cell Proteomics, 12 (3) 720-35.

Durand E., Bouchet S., Bertin P., Ressayre A., Jamin P., Charcosset A., Dillmann C., Tenaillon M. I. (2012) Flowering time in maize: linkage and epistasis at a major effect locus. Genetics, 190 (4) 1547-62.

Wang S., Spor A., Nidelet T., Montalent P., Dillmann C., de Vienne D., Sicard D. (2011) Switch between life history strategies due to changes in glycolytic enzyme gene dosage in Saccharomyces cerevisiae. Appl Environ Microbiol, 77 (2) 452-9.

Sabarly V., Bouvet O., Glodt J., Clermont O., Skurnik D., Diancourt L., de Vienne D., Denamur E., Dillmann C. (2011) The decoupling between genetic structure and metabolic phenotypes in Escherichia coli leads to continuous phenotypic diversity. J Evol Biol, 24 (7) 1559-71.

Albertin W., Marullo P., Aigle M., Dillmann C., de Vienne D., Bely M., Sicard D. (2011) Population size drives industrial Saccharomyces cerevisiae alcoholic fermentation and is under genetic control. Appl Environ Microbiol, 77 (8) 2772-84.

Spor A., Dillmann C., Wang S., de Vienne D., Sicard D., Parent E. (2010) Hierarchical Bayesian Modelling for Saccharomyces cerevisiae population dynamics. Int J Food Microbiol, 142 (1-2) 25-35.

Fievet J. B., Dillmann C., de Vienne D. (2010) Systemic properties of metabolic networks lead to an epistasis-based model for heterosis. Theor Appl Genet, 120 (2) 463-73.

Durand E., Tenaillon M. I., Ridel C., Coubriche D., Jamin P., Jouanne S., Ressayre A., Charcosset A., Dillmann C. (2010) Standing variation and new mutations both contribute to a fast response to selection for flowering time in maize inbreds. BMC Evol Biol, 10 2.

Johannes F., Porcher E., Teixeira F. K., Saliba-Colombani V., Simon M., Agier N., Bulski A., Albuisson J., Heredia F., Audigier P., Bouchez D., Dillmann C., Guerche P., Hospital F., Colot V. (2009) Assessing the impact of transgenerational epigenetic variation on complex traits. PLoS Genet, 5 (6) e1000530.

Edelist C., Raffoux X., Falque M., Dillmann C., Sicard D., Rieseberg L. H., Karrenberg S. (2009) Differential expression of candidate salt-tolerance genes in the halophyte Helianthus paradoxus and its glycophyte progenitors H. annuus and H. petiolaris (Asteraceae). Am J Bot, 96 (10) 1830-8.

Albertin W., Marullo P., Aigle M., Bourgais A., Bely M., Dillmann C., de Vienne D., Sicard D. (2009) Evidence for autotetraploidy associated with reproductive isolation in Saccharomyces cerevisiae: towards a new domesticated species. J Evol Biol, 22 (11) 2157-70.

Spor A., Wang S., Dillmann C., de Vienne D., Sicard D. (2008) "Ant" and "grasshopper" life-history strategies in Saccharomyces cerevisiae. PLoS One, 3 (2) e1579.

> Before 2008

Fiévet J., Dillmann C., Curien G. and de Vienne D. (2006) Simplified modelling of metabolic pathways for flux prediction and optimization: lessons from an in vitro reconstruction of the upper part of glycolysis. Biochem. J. 396: 17-26.

Edelist C., Lexer C., Dillmann C., Sicard D. and Rieseberg L.H. (2006) Microsatellite signature of ecological selection for salt tolerance in a wild sunflower hybrid species, Helianthus paradoxus. Molecular Ecology 15(14): 4623.

Lion S., Gabriel F., Bost B., Fiévet J., Dillmann C. and de Vienne D. (2004) An extension to the metabolic control theory taking into account correlations between enzyme concentrations. Eur. J. Biochem 271 :1-17.

Fiévet J., Lagneil G., Dillmann C., Davanture M., Labarre J. and de Vienne D. (2004) Assessing factors for reliable quantitative proteomics based on two-dimensional electrophoresis. Proteomics, 4, 1939-1949.

Degent T., Dillmann C., Marion-Poll F. and Turling T. (2004) High genetic variability of herbivore-induced volatile emission within a broad range of maize inbred lines. Plant Physiology 135 :1928-1938.

Servin B., Dillmann C., Decoux G. and Hospital F. (2002) MDM: a program to compute fully informative genotype frequencies in complex breeding schemes. J Hered 93: 227-228.

de Vienne D., Bost B., Fiévet J., Zivy M., and Dillmann C. (2001) Variabilité d'expression du proteome et heterosis. C.R. Acad. Agric. Fr. 87: 27-38.

de Vienne D., Bost B., Fiévet J. and Dillmann C. (2001) Optimization of enzyme concentrations for unbranched reaction chains: the concept of combined response coefficient. Acta Biotheoretica 49: 341-350.

de Vienne D., Bost B., Fiévet J., Zivy M. and Dillmann C. (2001) Genetic variability of proteome expression and metabolic control. Plant Physiol. Biochem. 39:1-13.

Bost B., de Vienne D., Hospital F., Moreau L. and Dillmann C. (2001) Genetic and non genetic bases for the L-shaped distribution of QTL effects. Genetics 157 :1773-1787.

Roldan-Ruiz I., Van Euwijk F.A. , Gilliland T. J., Dubreuil P., Dillmann C., Lallemand J., De Loose M., Baril C.P. (2001) A comparative study of molecular and morphological methods of describing relationships between perennial ryegrass (Lolium perenne L.) varieties. Theoretical and Applied Genetics 103 : 1138-1150.

Bost B., Dillmann C. and de Vienne D. (1999) Fluxes and metabolic pools as model traits for quantitative genetics. I The L-shaped distribution of gene effects. Genetics 153: 2001-2012.

Dillmann C. and Foulley J.L. (1998) Another look at multiplicative models in quantitative genetics. Gen. Sel. Evol. 30:543-564.

Dillmann C. and Guérin D. (1998) Comparison between maize inbred lines: genetic distances in the expert�s eye. Agronomie 18:659-667.

Dillmann C., Bar-Hen A., Guérin D., Murigneux A. and Charcosset A. (1997) Comparison of RFLP and morphological distances between maize inbreds. Consequences for germplasm protection purposes. Theor. Appl. Genet. 95:92-102.

Hospital F., Dillmann C. and Melchinger A. E. (1996) A general algorithm to compute multilocus genotype frequencies under various mating systems. Comput. Appl. Biosci. 12(6):455-462.

Ciampolini R., Goudarzi K., Vaiman D., Dillmann C., Mazzantin E., Foulley J.L., Leveziel H., Cianci D. (1995) Individual multilocus genotypes using microsatellite polymorphism to permit the analysis of genetic variability. J. Anim. Sci. 73:3259-3268.

Garnier P. and Dillmann C. (1992) A computer program for testing pairwise linkage disequilibria in subdivided populations. Journal of Heredity 83:3.