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portrait Julie FiévetJulie FIÉVET


Hybrid vigor and inbreeding depression in Maize

Génétique Quantitative et Évolution - Le Moulon
INRA - Université Paris-Sud - CNRS - AgroParisTech
Ferme du Moulon
Tel: 01 69 33 23 58
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> Position

Associate Professor (MC) Agroparistech

Departement of Life Science and Health,  Team Evolutionnary Genetics and Plant Breeding, Research conducted in the laboratory Génétique Quantitative et Méthodologie de la Sélection, GQE - Le Moulon

Co-supervisor of the Master of Engineering Production and Innovation in Plant Systems (PISTv) in AgroParisTech

Co-supervisor of the T.I.P.E exam (student project of science) for the selective admission process to National Institute of Higher Education in Agricultural and Veterinary Sciences

> Education

  • Postdoctoral fellow, GQE-Le Moulon (Gif-sur-Yvette, France), 2007
  • Postdoctoral fellow, Physiologie Cellulaire Végétale, CEA Grenoble, 2005-2007
  • PhD student (MENRT fellowship), UMR Génétique Végétale (Gif-sur-Yvette, France), 2000-2004

> Research interests, accomplishment and expertiseheterosis

My current research interests are focus on the phenomenons of hybrid vigor and inbreeding depression. My main objectives are to investigate with a high resolution the genetic determinants of heterosis to address in particular (i) the respective roles played by overdominance and pseudo-overdominance and (ii) the contribution of structural variation (presence absence of genes) to heterosis relatively to other types of polymorphisms. I also investigate to which extent heterosis is related to the combination of complementary adaptation factors in parental materials. My research takes place within the French investment for the future Amaizing program, in which I lead the heterosis task in the WP5 and WP6 (

My past work has been to investigate how the Metabolic Control Theory could lead to a biochemical model of heterosis based on the definition of dominance and overdominance as emergent properties of metabolic systems.

During my postdoctoral fellow in the PCV lab, I’ve worked on the plant response to heavy metal stress in the context of phytoremediation.


> Teaching

Master of Engineering

1st year Population and Quantitative Genetics

2nd year Plant Genetics and Breeding ; Plant Adaptation to Abiotic Stresse

3rd year

- Production et Innovation dans les Systèmes Techniques Végétaux (PISTv)
Plant breeding ; Quantitative Genetics ; Population Genetics ; Genome Wide Selection and Association Studies

- Biotechnologies (BIOTECH)
Quantitavive Genetics ; Biostatistics ; Metabolic Engineering

Master of science

Biologie Intégrative et Physiologie / M. Sc degree of the Paris-Saclay University
Genetics and Diversity ; Plant breeding ; Biostatistics
More information

Bachelor of Science – Institut Villebon Charpak

Population Genetics ; Plant Genetics and Breeding
More information


> Selected publications

Hybrid vigor & Heterosis

Fievet J., Nidelet T., Dillmann C., de Vienne D. (2018) Heterosis is a systemic property emerging from nonlinear genotype-phenotype relationships: evidence from in vitro genetics and computer simulations. Front Genet, 9 159. F1000Prime Recommendations, Dissents and Comments for [Fiévet JB et al., Front Genet 2018 , 9:159]. In F1000Prime, 12 Jul 2018;

Larièpe A., Moreau L., Laborde J., Bauland C., Mezmouk S., Décousset L., Mary-Huard T., Fiévet J.B., Gallais A., Dubreuil P., Charcosset A. (2016) General and specific combining abilities in a maize (Zea mays L.) test-cross hybrid panel: relative importance of population structure and genetic divergence between parents. Theor Appl Genet doi: 10.1007/s00122-016-2822-z

Larièpe A. , Mangin B., Jasson S., Combes V., Dumas F., Jamin P., Lariagon C., Jolivot D., Madur D., Fievet J.B., Gallais A., Dubreuil P., Charcosset A., Moreau L. (2012) The genetic basis of heterosis: multiparental QTL mapping reveals contrasted levels of apparent overdominance among traits of agronomical interest in maize (Zea mays L.). Genetics 190: 795-811

Fievet J.B., Gallais A. & de Vienne D. (2011) Heterosis, inbreeding depression and hybrid varieties. In J.L. Prioul, C. Thévenot and T. Molnar (eds). Advances in Maize (Essential Reviews in Experimental Biology) (Vol.3), Society for Experimental Biology, UK.

Fievet J.B., Dillmann C. & de Vienne D. (2010) Systemic properties of metabolic networks lead to an epistasis-based model for heterosis. Theor Appl Genet. 120:463-473

Plant Response to heavy metal stresses

Doustaly F*, Combes F*, Fievet J.B*, Berthet S, Hugouvieux V, Bastien O, Aranjuelo I, Leonhard N, Rivasseau C, Carrière M, Vavasseur A, Renou J P, Vandenbrouck Y, Bourguignon J (2014) Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots. Metallomics 6: 809-821.

Ducruix C., Vailhen D., Werner E., Fievet J.B., Bourguignon J., Tabet J-C, Ezan E., Junot C. (2008) Metabolomic investigation of the response of the model plant Arabidopsis thaliana to cadmium exposure: evaluation of data pre-treatment methods for further statistical analysis. Chemometrics and Intelligent Laboratory Systems 91: 67-77

Ducruix C., Junot C., Fievet J.B., Villiers F., Ezan E., Bourguignon J. (2006) New insights into the regulation of phytochelatin biosynthesis in Arabidopsis thaliana cells from metabolite profiling analysis. Biochimie 88: 1733-1742

Sarry J.E., Kuhn L., Ducruix C., Lafaye A., Junot C., Hugouvieux V., Jourdain A., Bastien O., Fievet J.B., Vailhen D., Amekraz B., Moulin C., Ezan E., Garin J., Bourguignon J. (2006) The early response of Arabidopsis thaliana cells to cadmium exposure explored by protein and metabolite profiling analyses. Proteomics 6: 2180-2198.