maud
 
Maud Tenaillon 
Evolutionary genetics
    Genetic diversity and plant domestication   

    CNRS researcher, Dept. Plant Genetics
                           Ferme du Moulon

            Currently on sabbatical leave at the
              University of California Irvine
                            in the Gaut lab

    Contact information
    Dept. of Ecology and Evolutionary Biology
    University of California Irvine
    321 Steinhaus Hall    
    Irvine CA 92697
    USA

   phone: + 00 1 949 824 2963
    fax: + 00 1 949 824 2181
    email: maud.tenaillon@uci.edu


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Research    
Pictures    



Research Interest

My research focus on understanding how the evolutionary forces shape the genetic variation of plant genomes in relation with adaptation. I have a particular interest for plant domestication as a model of adaptation. At the genome level, domestication involved a loss of diversity resulting from both a bottleneck and selection at target genes. I've been working on depicting this process in a selfer plant, the foxtail millet, adressing questions such as: What are the genetic basis of domestication? Is there an influence of the breeding system on the organization of domesticated genes? I am currently focusing on maize as a model species. I investigated the influence of recombination and selection in shaping patterns of both nucleotide  and  microsatellite diversity in this species. I worked both: at a small scale in between two loci, one has been subjected to strong selection during domestication and the other has been involved in climate adaptation; and at a broader scale considering multiple loci. In particular, I developped a multilocus model to investigate the impact of demography (domestication bottleneck) on diversity and long distance linkage disequilibrium. This model was applied in a large dataset to identify loci under selection in maize. I am currently developping two main projects. One project examines the evolution in Angiosperms of a multigene family encoding a key enzyme of the starch pathway and aims at characterizing the forces that primarly determine the fate of duplicated genes. Because increase in starch content is considered as a major domestication trait, I also focus on the expression and patterns of variability of these duplicates in maize and its wild progenitor. The second project aims at investigating the role of transposable elements (TEs) in the domestication process. Using markers that reveal the polymorphism of insertion of TEs, I want to unravel the demographic history of maize populations and to identify insertions that may have contributed to local adaptation. Recent collaborative projects concern the historical divergence and gene flow in the genus Zea (collaboration with B. Gaut and J. Ross-Ibarra), the demographic history of Drosophilla sechellia (collaboration with D. Legrand and M-L Cariou) and the contribution of standing variation and new mutations in a divergent selection experiment for flowering time in maize (collaboration with C. Dillmann, A. Charcosset, E. Durand). 

Current and past year collaborators on those projects include
Former PhD student and postdoc: L. Camus-Kulandaivelu, T. Zerjal
PhD students: J. Corbi  (cosupervision with D. Manicacci), E. Durand (cosupervision with C. Dillmann and A. Charcosset)
Members of the GEAR research group (D. Manicacci, K. Alix-Jenczewski, C. Vitte, C. Damerval)
Members of the department (C. Dillmann and A. Charcosset)
Other French research groups (M-A. Grandbastien and C. Mhiri from INRA Versailles; D. Legrand and M-L Cariou from LEGS; F. Austerlitz and L-M Chevin from ESE; O. Tenaillon from INSERM U722; A-C Thuillet from IRD)
Abroad researchers: B. Gaut (UC Irvine), J. Ross-Ibarra (UC Irvine), P. Tiffin (U of Minnesota)

Positions and Education

CNRS researcher (CR1), Department of Plant Genetics, Ferme du Moulon (France), 2002-present
HDR defended in April 2009 (University of Orsay)
Postdoctoral fellow (NSF) in the Gaut lab , Department of Ecology and Evolutionary Biology, UC Irvine (USA), 1999-2002
PhD student, Department of Evolution and Systematic , University of Orsay (France), 1995-1999


 Publications

icone Parisod C., Salmon A., Zerjal T.,  Tenaillon M., Grandbastien M-A., Ainouche M. (in press). Rapid structural and epigenetic reorganization near transposable element in hybrid and allopolyploid genomes in Spartina. New Phytologist.
icone Zerjal T., Joets J., Alix K., Grandbastien M-A., Tenaillon M.I. (2009). Contrasting evolutionary patterns and target specificities among three Tourist-like MITE families in the maize genome. Plant Molecular Biology. 71:99-114.
icone Legrand D., Tenaillon M.I., Matyot P., Gerlach J., Lachaise D., Cariou M-L. (2009). Species–wide genetic variation and demographic history of Drosophila sechellia, a species lacking population structure. Genetics. 182:1197-1206.
icone Ross-Ibarra J., Tenaillon M.I., Gaut B.S. (2009). Historical divergence and gene flow in the genus Zea. Genetics. 181:1399-1413.
icone Camus-Kulandaivelu L., Chevin L-M., Tollon C., Charcosset  A., Manicacci D., Tenaillon M.I. (2008). Patterns of variation of the Tb1-D8 region shed light into early maize evolutionary history. Genetics. 180:1107-1121.
icone Tenaillon M.I. and Tiffin P.L. (2008). The quest for adaptive evolution: a theoretical challenge in a maze of data. Curr. Opin. Plant Biol. 11(2):110-115.
icone Tenaillon M.I., Austerlitz F. and Tenaillon O. (2008). Apparent mutational hotspots and long distance LD resulting from a bottleneck. J. Evol. Biol. 21(2):541-550.
icone Thuillet A-C., Tenaillon M.I., Anderson L.K., Mitchell S.E., Kresovich S., Stack S.M., Gaut B.S. and Doebley J (2008). A weak effect of background selection on trinucleotide microsatellites in maize. J. of Heredity. 99(1): 45-55.
icone Moeller D.A., Tenaillon M.I. and Tiffin P. (2007). Population structure and its effects on patterns of nucleotide polymorphism in the teosinte (Zea mays ssp. parviglumis). Genetics 176(3):1799-1809.
icone Yamasaki M., Tenaillon M. I., Vroh Bi I., Schroeder S.G., Sanchez-Villeda H., Doebley J.F., Gaut B.S., and McMullen M.D. (2005). A large scale screen for artificial selection in maize identifies candidate agronomic loci for domestication and crop improvement. Plant Cell 17(11):2859-2872.
pdficone Tenaillon M. I., U'Ren J., Tenaillon O., and Gaut B.S. (2004). Selection versus demography: a multilocus investigation of the domestication process in maize. Mol. Biol. Evol. 21(7): 1214-1225.
icone Tenaillon M. I., Sawkins M. C., Anderson L. K., Stack S. M., Doebley   J., and Gaut B. S.(2002). Patterns of diversity and recombination along chromosome 1 of maize (Zea mays ssp. mays L.) . Genetics. 162: 1401-1413.
icone  Whitt S. R., Wilson L. M., Tenaillon M. I., Gaut B. S., and Buckler E. S.4th. (2002). Genetic diversity and selection in the maize starch pathway. Proc. Natl. Acad. Sci. U.S.A. 99: 12959-12962.
icone Tenaillon M. I., Sawkins M. C., Long A. D., Gaut R. L., Doebley J. F., and Gaut B. S. (2001). Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea mays ssp. mays L.). Proc. Natl. Acad. Sci. U. S. A. 98: 9161-9166.
icone  Gaut B. S., Le Thierry d'Ennequin M., Peek A. S., and Sawkins M. C. (2000). Maize as a model for the evolution of plant nuclear genome. Proc. Natl. Acad. Sci. U. S. A. 97: 7008-7015.
icone  Le Thierry d'Ennequin M., Panaud O., and Sarr A. (2000). Assessment of genetic relationships between Setaria italica and its wild progenitor, S. viridis using AFLP markers to elucidate the origin of foxtail millet domestication. Theor. and Appl. Genet. 100: 1061-1066.
icone Le Thierry d'Ennequin M., Toupance B., Robert T., Godelle B., and Gouyon P.-H. (1999).  Plant domestication: a model for  studying the evolution of linkage. Journal of Evolutionary Biology 12 : 1138-1147.
icone   Le Thierry d'Ennequin M., Panaud O., Brown S., Siljak-Yakovlev S., and Sarr A. (1998).  First evaluation of nuclear DNA content by flow cytometry in Setaria gene pool . Journal of Heredity 89:  556-559.
icone  Le Thierry d'Ennequin M., Panaud O., Robert T., and Ricroch A. ( 1997). Assessment of genetic relationships among sexual and asexual forms of Allium cepa using morphological traits and RAPD markers. Heredity 78: 403-409.


Family pictures
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