crossing teosintes

Maud Tenaillon

Genome Dynamics and Adaptation of cultivated Plants

CNRS researcher
Dept. Quantitative Genetics and Evolution

    Contact information
    Génétique Quantitative et Evolution - Le Moulon
    Ferme du Moulon
    91190 Gif-sur-Yvette    

   phone: + 33 (0) 69 33 23 34
    fax: + 33 (0) 1 69 33 23 40


Research Interest

My research focus on understanding how the evolutionary forces shape the genetic variation of plant genomes in relation with adaptation

At the genome level, domestication involved a loss of diversity resulting from both a bottleneck and selection at target genes. During my PhD, I've been working on depicting this process in a selfer plant, the foxtail millet, adressing questions such as: What are the genetic basis of domestication? Is there an influence of the breeding system on the organization of domesticated genes?

Since then I've been focusing on maize as a model species. I investigated the influence of recombination and selection in shaping patterns of nucleotide and microsatellite diversity in this species. I worked both: at a small scale in between two loci, one has been subjected to strong selection during domestication and the other has been involved in climate adaptation; and at a broader scale considering multiple loci. In particular, I developed a multilocus model to investigate the impact of demography (domestication bottleneck) on diversity and long distance linkage disequilibrium. This model was applied in a large dataset to identify loci under selection in maize. Because increase in starch content is considered as a major domestication trait, I studied the evolution of multigene families encoding enzymes of the starch biosynthesis pathway. The aim was to characterize the forces that primarly determine the fate of duplicated genes, and to describe the patterns of expression and variability of these duplicates in maize and its wild progenitors - the teosintes. I worked on questions related to genome size variation within and among species in the Zea genus, both from a genomic - Transposable Element (TE) content - and an ecological perspective.

I am currently working on three main projects. The first project concerns the characterization of European maize, its demographic and adaptive history linked to recent introduction(s) at the end of the 15th century. We have generated whole-genome sequencing (WGS) of 67 maize genomes. The second project aims at investigating the genetic bases of local adaptation in teosinte populations along altitudinal gradients with a special emphasis on TEs. The focus of the third project is the study of the maize floral transition network. A main objective is to identify the (epi)mutations involved in an experimental evolution setting in which divergent selection for flowering time has been applied for over 20 generations.   

Current collaborators on those projects include
Current PhD students N. Martinez-Ainsworth and A. Desbiez-Piat
Former Postdoc J-T Brandenburg
Former PhD student M-A. Fustier

Members of the DyGAP research group D. Manicacci, C. Vitte, J. Joets, A. Cornille, technical help from H. Corti, A. Rousselet and M. Le Guilloux
Members of the department C. Dillmann and A. Ressayre S. Nicolas and A. Charcosset and T. Mary-Huart, M. Falque, J. Enjalbert
Other French research groups Y. Vigouroux and D. Grimanelli at IRD (Montpellier), Y. Moenne-Loccoz (Lyon), M. Carraretto (Toulouse), C. Palaffre (Saint-Martin-de-Hinx),
Abroad researchers: B. Gaut (UC Irvine, USA), J. Ross-Ibarra (UC Davis, USA), L. Eguiarte (UNAM, Mexico), J. Aguirre (UNAM, MExico), S. Montes (INIFAP, Celaya), J. de Meaux (Univ. Cologne).

Past collaborators
S. Boitard from INRA Toulouse
Former master student J. Lapeyronnie
Former student K. Seddiki
Former master student M. Mollion
Former master student O. Nougué
Former postdoc T. Zerjal, C. Muñoz Diez
Former PhD students L. Camus-Kulandaivelu, J. Corbi, E. Durand
T. Giraud at ESE (Orsay)
O. Tenaillon from INSERM U722 Univ. Paris 7
M-A. Grandbastien and C. Mhiri from INRAVersailles
D. Legrand and M-L Cariou
F. Austerlitz (MHNH Paris) and L-M Chevin (CEFE Montpellier)
A-C Thuillet from IRD Montpellier
P. Tiffin from University of Minnesota (USA)
M. Hufford from Iowa State University (USA) 

Positions and Education

CNRS researcher (DR2), Department of Plant Genetics, Ferme du Moulon (France), 2002-present
Awarded by the CNRS bronze medal in 2011
Visiting researcher in the Gaut lab at UC Irvine, 2009-2011
HDR defended in April 2009 (University of Orsay)
Postdoctoral fellow (NSF) in the Gaut lab , Department of Ecology and Evolutionary Biology, UC Irvine (USA), 1999-2002
PhD student, Department of Evolution and Systematic , University of Orsay (France), 1995-1999


iconeOdonkor S., Martinez-Bello L., Wang X., Bahri B.A., Choi S., Chakraborty D., Tenaillon M.I., Panaud O., Devos K.M. (in press). QTL mapping combined with comparative analyses identified genes for non-shattering in Setaria italica. Frontiers in Plant Science.

iconeKäfer J., Betancourt A., Villain A.S., Fernandez M., Vignal C., Marais G.A.B., Tenaillon M.I. (2018). Progress and Prospects in gender visibility at SMBE annual meetings. Genome Biology and Evolution. 10(3):901-908.

iconeAguirre-Liguori J.A., Tenaillon M.I., Vázquez-Lobo A., Gaut B.S., Jaramillo-Correa J-P., Montes-Hernandez S., Souza V., Eguiarte L.E. (2017). Connecting genomic patterns of local adaptation and niche suitability in teosintes. Molecular Ecology. 26(16):4226-4240

iconeBrandenburg J-T., Mary-Huard T., Rigaill G., Hearne S., Corti H., Joets J., Vitte C., Charcosset A., Nicolas S., Tenaillon M.I. (2017). Independent introductions and admixtures have contributed to adaptation of European maize and its American counterparts. PLOS Genetics. 3(3):e1006666.

iconeFustier M-A., Brandenburg J.T., Lapeyronnie J., L.E. Eguiarte, Boitard S., Vigouroux Y., Manicacci D., Tenaillon M.I. (2017). Local adaptation of teosintes along altitudinal gradients using whole genome sequencing of pooled samples. Molecular Ecology: 26(10):2738-2756.

iconeBerthouly-Salazar C., Thuillet A-C., Rhoné B., Mariac C., Ousseini I.S., Couderc M., Tenaillon M.I., Vigouroux Y (2016). Genome scan reveals selection acting on genes linked to stress     response in wild pearl millet. Molecular Ecology. 25(21):5500-5512.

iconeTenaillon M.I., Manicacci D., Nicolas S., Tardieu F., Welcker C. (2016). Testing the link between genome size and growth rate in a collection of maize inbred lines. Peer J. 4:e2408.

iconeMartínez-Ainsworth N.E., Tenaillon M.I. (2016). Superheroes and masterminds of plant domestication. Comptes rendus de l’Académie des Sciences Biologies. 339(7-8) :268.

icone Durand E., Tenaillon M.I., Raffoux X., Thépot S., Jamin P., Bourgais A., Ressayre A., Dillmann C. (2015). Dearth of polymorphism associated with a sustained response to selection for flowering time in maize. BMC Evolutionary Biology. 15:103.

icone Vitte C., Fustier M-A., Alix K., Tenaillon M.I. (2015). The bright side of transposons in crop evolution. Briefings in Functional Genomics. 13 (4): 276-295.

icone Nougué O., Corbi J., Ball S.G., Manicacci D., Tenaillon M.I. (2014). Molecular evolution accompanying functional divergence of duplicated genes along the plant starch biosynthesis pathway. BMC Evolutionary Biology. 14:103.

icone Munoz Diez C., Meca E., Tenaillon M.I., Gaut B.S. (2014). Three groups of transposable elements with contrasting copy number dynamics and host responses in the maize (Zea mays ssp. mays) genome. Plos Genetics. 10(4): e1004298.

icone  Munoz Diez C., Gaut B.S., Meca E., Scheinvar E., Montes-Hernandez S., Eguiarte L., Tenaillon M.I. (2013). Genome size variation in wild and cultivated maize along altitudinal gradients. NewPhytologist. 199: 264-276.

icone  Hufford M., Martinez-Meyer E., Gaut B.S., Eguiarte L.E., Tenaillon M.I. (2012). Inferences from the historical distribution of wild and domesticated maize provide ecological and evolutionary insight. PLoS ONE. 7(11): e47659.

icone  Munoz Diez C., Vitte C., Ross-Ibarra J., Gaut B.B., Tenaillon M.I. (2012). Using nextgen sequencing to investigate genome size variation and transposable element content. Book chapter in Plant Transposable Elements (Topics in current genetics). 24: 41-58.

icone Chia J-M., Song C., Bradbury P.J., Costich D.,... Tenaillon M.I., ... Buckler E.S., Zhang G., Xu Y., Ware D. (2012). Maize HapMap2 identifies extant variation from a genome in flux. Nature Genetics. 44:803-807.
icone Cornille A., Gladieux P., Smulders M.J.M., Roldan-Ruiz I., Laurens F., Le Cam B., Nersesyan A., Clavel J., Olonova M., Feugey L., Gabrielyan I., Zhang X-G., Tenaillon M.I., Giraud T. (2012). New insights into the history of domesticated apple: secondary contribution by several wild species to the genome of cultivated species. Plos Genetics. 8: e1002703.
icone Zerjal T., Rousselet A., Mhiri C., Combes V., Madur D., Grandbastien M-A., Charcosset A., Tenaillon M.I. (2012). Maize genetic diversity and association mapping using transposable element insertion polymorphisms. Theoretical and Applied Genetics. 124: 1521-1537. 
icone Durand E., Bouchet S., Bertin P., Ressayre A., Jamin P., Charcosset A., Dillmann C., Tenaillon M.I. (2012). Epistasis, pleiotropy and maintenance of polymorphism at a locus associated with flowering time variation in maize inbred lines. Genetics. 190: 1547-1562.
icone Corbi J., Dutheil J., Damerval C., Tenaillon M.I., Manicacci D. (2012). Accelerated evolution and coevolution drove the evolutionary history of AGPase subunits during Angiosperm radiation. Annals of Botany. 109: 693-708.
icone Tenaillon M.I., Manicacci D. (2011). Maize origins: an old question under the spotlights. Book chapter in Advances in Maize (Essential reviews in Experimental Biology). 3: 89-110.
icone Tenaillon M.I., Hufford, Gaut B.S., Ross-Ibarra J. (2011). Genome size and transposable element content as determined by high-thoughput sequencing in maize and Zea luxurians. Genome Biology and Evolution. 3: 219-229.
icone Tenaillon M.I., Charcosset A. (2011). A European perspective on maize history. Comptes rendus de l'Académie des sciences. 334: 221-228.
icone Corbi J., Debieu M., Rousselet A. Montalent P., Leguilloux M., Manicacci D., Tenaillon M.I. (2011). Contrasted patterns of selection since maize domestication on duplicated genes encoding a starch pathway enzyme. Theoretical and Applied Genetics. 122: 705-722.
icone Tenaillon M.I., Hollister J.D., Gaut B.S. (2010). A Triptych of the evolution of plant transposable elements. Trends in Plant Science. 15(8): 471-478.
icone Durand E., Tenaillon M.I., Ridel C., Coubriche D., Jamin P., Jouanne S., Charcosset A., Dillmann C. (2010). Standing variation and new mutations both contribute to a fast response to selection for flowering time in maize inbreds. BMC Evolutionary Biology. 10:2.
icone Parisod C., Salmon A., Zerjal T.,  Tenaillon M., Grandbastien M-A., Ainouche M. (2009). Rapid structural and epigenetic reorganization near transposable element in hybrid and allopolyploid genomes in Spartina. New Phytologist. 184(4):1003-1015.
icone Zerjal T., Joets J., Alix K., Grandbastien M-A., Tenaillon M.I. (2009). Contrasting evolutionary patterns and target specificities among three Tourist-like MITE families in the maize genome. Plant Molecular Biology. 71:99-114.
icone Legrand D., Tenaillon M.I., Matyot P., Gerlach J., Lachaise D., Cariou M-L. (2009). Species–wide genetic variation and demographic history of Drosophila sechellia, a species lacking population structure. Genetics. 182:1197-1206.
icone Ross-Ibarra J., Tenaillon M., Gaut B.S. (2009). Historical divergence and gene flow in the genus Zea. Genetics. 181:1399-1413.
icone Camus-Kulandaivelu L., Chevin L-M., Tollon C., Charcosset  A., Manicacci D., Tenaillon M.I. (2008). Patterns of variation of the Tb1-D8 region shed light into early maize evolutionary history. Genetics. 180:1107-1121.
icone Tenaillon M.I. and Tiffin P.L. (2008). The quest for adaptive evolution: a theoretical challenge in a maze of data. Current Opinion in Plant Biology. 11(2):110-115.
icone Tenaillon M.I., Austerlitz F. and Tenaillon O. (2008). Apparent mutational hotspots and long distance LD resulting from a bottleneck. Journal of Evolutionary Biology. 21(2):541-550.
icone Thuillet A-C., Tenaillon M.I., Anderson L.K., Mitchell S.E., Kresovich S., Stack S.M., Gaut B.S. and Doebley J (2008). A weak effect of background selection on trinucleotide microsatellites in maize. Journal of Heredity. 99(1): 45-55.
icone Moeller D.A., Tenaillon M.I. and Tiffin P. (2007). Population structure and its effects on patterns of nucleotide polymorphism in the teosinte (Zea mays ssp. parviglumis). Genetics. 176(3):1799-1809.
icone Yamasaki M., Tenaillon M. I., Vroh Bi I., Schroeder S.G., Sanchez-Villeda H., Doebley J.F., Gaut B.S., and McMullen M.D. (2005). A large scale screen for artificial selection in maize identifies candidate agronomic loci for domestication and crop improvement. Plant Cell. 17(11): 2859-2872.
pdficone Tenaillon M. I., U'Ren J., Tenaillon O., and Gaut B.S. (2004). Selection versus demography: a multilocus investigation of the domestication process in maize. Molecular Biology and Evolution. 21(7): 1214-1225.
icone Tenaillon M. I., Sawkins M. C., Anderson L. K., Stack S. M., Doebley   J., and Gaut B. S.(2002). Patterns of diversity and recombination along chromosome 1 of maize (Zea mays ssp. mays L.) . Genetics. 162: 1401-1413.
icone  Whitt S. R., Wilson L. M., Tenaillon M. I., Gaut B. S., and Buckler E. S.4th. (2002). Genetic diversity and selection in the maize starch pathway. Proc. Natl. Acad. Sci. USA. 99: 12959-12962.
icone Tenaillon M. I., Sawkins M. C., Long A. D., Gaut R. L., Doebley J. F., and Gaut B. S. (2001). Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea mays ssp. mays L.). Proc. Natl. Acad. Sci. USA. 98: 9161-9166.
icone  Gaut B. S., Le Thierry d'Ennequin M., Peek A. S., and Sawkins M. C. (2000). Maize as a model for the evolution of plant nuclear genome. Proc. Natl. Acad. Sci. USA. 97: 7008-7015.
icone  Le Thierry d'Ennequin M., Panaud O., and Sarr A. (2000). Assessment of genetic relationships between Setaria italica and its wild progenitor, S. viridis using AFLP markers to elucidate the origin of foxtail millet domestication. Theoretical and Applied Genetics. 100: 1061-1066.
icone Le Thierry d'Ennequin M., Toupance B., Robert T., Godelle B., and Gouyon P.-H. (1999).  Plant domestication: a model for  studying the evolution of linkage. Journal of Evolutionary Biology. 12 : 1138-1147.
icone   Le Thierry d'Ennequin M., Panaud O., Brown S., Siljak-Yakovlev S., and Sarr A. (1998).  First evaluation of nuclear DNA content by flow cytometry in Setaria gene pool . Journal of Heredity. 89:  556-559.
icone  Le Thierry d'Ennequin M., Panaud O., Robert T., and Ricroch A. ( 1997). Assessment of genetic relationships among sexual and asexual forms of Allium cepa using morphological traits and RAPD markers. Heredity. 78: 403-409.