phone: + 33 (0) 69 33 23
|| Research Interest
My research focus on understanding how the evolutionary forces shape the genetic variation of plant genomes in relation with adaptation. I have a particular interest for plant domestication as a model of adaptation.
At the genome level, domestication involved a loss of diversity resulting from both a bottleneck and selection at target genes. During my PhD, I've been working on depicting this process in a selfer plant, the foxtail millet, adressing questions such as: What are the genetic basis of domestication? Is there an influence of the breeding system on the organization of domesticated genes?
Since then, I've been focusing on maize as a model species. I investigated the influence of recombination and selection in shaping patterns of both nucleotide and microsatellite diversity in this species. I worked both: at a small scale in between two loci, one has been subjected to strong selection during domestication and the other has been involved in climate adaptation; and at a broader scale considering multiple loci. In particular, I developed a multilocus model to investigate the impact of demography (domestication bottleneck) on diversity and long distance linkage disequilibrium. This model was applied in a large dataset to identify loci under selection in maize.
I am currently working on three main projects. One project examines the evolution in Angiosperms of a multigene family encoding a key enzyme of the starch pathway and aims at characterizing the forces that primarly determine the fate of duplicated genes. Because increase in starch content is considered as a major domestication trait, I also focus on the expression and patterns of variability of these duplicates in maize and its wild progenitor (teosintes). The second project concerns the characterization of European maize, its demographic and adaptive history linked to recent introduction(s) at the end of the 15th century. Next Generation Sequencing tools will be used to generate data from 70 maize genomes. The third project aims at investigating the genetic basis of adaptation in wild teosinte populations along altitudinal gradients with a special emphasis on transposable elements (TEs) and epigenetic variation. Using NGS, I want to unravel the demographic history of teosintes and to identify the determinants of local adaptation.
Current collaborative projects concern the evolution of genome size in the Zea genus and the contribution of new (epi)mutations in a divergent selection experiment for flowering time in maize.Current collaborators on those projects include
Current Postdoc J-T Brandenburg
Current PhD student M-A Fustier
Former master student O. Nougué
Former PhD student E. Durand
Former Postdoc C. Muñoz Diez
Members of the GEAR research group D. Manicacci, C. Vitte, technical help from A. Rousselet and M. Le Guilloux
Members of the department C. Dillmann and A. Ressayre, J. Joets, S. Nicolas and A. Charcosset, M. Falque
Other French research groups Y. Vigouroux and D. Grimanelli at IRD (Montpellier), C. Charon at IBP (Gif-sur-Yvette), C. Montchamp-Moreau and C. Wicker-Thomas at LEGS (Gif-sur-Yvette)
Abroad researchers: B. Gaut (UC Irvine, USA), J. Ross-Ibarra (UC Davis, USA), M. Hufford (UC Davis, USA), L. Eguiarte (UNAM, Mexico)
Former postdoc T. Zerjal
Former PhD student L. Camus-Kulandaivelu, J. Corbi
T. Giraud at ESE (Orsay)
O. Tenaillon from INSERM U722 Univ. Paris 7
M-A. Grandbastien and C. Mhiri from INRAVersailles
D. Legrand and M-L Cariou from LEGS Gif-sur-Yvette
F. Austerlitz and L-M Chevin from ESE Univ. Orsay
A-C Thuillet from IRD Montpellier
P. Tiffin from University of Minnesota (USA)
Ferme du Moulon (France), 2002-present
Awarded by the CNRS bronze medal in 2011
Visiting researcher in the Gaut lab at UC Irvine, 2009-2011
HDR defended in April 2009 (University of Orsay)
Postdoctoral fellow (NSF) in the Gaut lab , Department of Ecology and Evolutionary Biology, UC Irvine (USA), 1999-2002
PhD student, Department of Evolution and Systematic , University of Orsay (France), 1995-1999
Hufford M., Martinez-Meyer E., Gaut B.S., Eguiarte L.E., Tenaillon M.I. (2012). Inferences from the historical distribution of wild and domesticated maize provide ecological and evolutionary insight. PLoS ONE. 7(11): e47659.
Munoz Diez C., Vitte C., Ross-Ibarra J., Gaut B.B., Tenaillon M.I. (2012). Using nextgen sequencing to investigate genome size variation and transposable element content. Book chapter in Plant Transposable Elements (Topics in current genetics). 24: 41-58.Chia J-M., Song C., Bradbury P.J., Costich D.,... Tenaillon M.I., ... Buckler E.S., Zhang G., Xu Y., Ware D. (2012). Maize HapMap2 identifies extant variation from a genome in flux. Nature Genetics. 44:803-807.
Cornille A., Gladieux P., Smulders M.J.M., Roldan-Ruiz I., Laurens F., Le Cam B., Nersesyan A., Clavel J., Olonova M., Feugey L., Gabrielyan I., Zhang X-G., Tenaillon M.I., Giraud T. (2012). New insights into the history of domesticated apple: secondary contribution by several wild species to the genome of cultivated species. Plos Genetics. 8: e1002703.
Zerjal T., Rousselet A., Mhiri C., Combes V., Madur D., Grandbastien M-A., Charcosset A., Tenaillon M.I. (2012). Maize genetic diversity and association mapping using transposable element insertion polymorphisms. Theoretical and Applied Genetics. 124: 1521-1537.
Durand E., Bouchet S., Bertin P., Ressayre A., Jamin P., Charcosset A., Dillmann C., Tenaillon M.I. (2012). Epistasis, pleiotropy and maintenance of polymorphism at a locus associated with flowering time variation in maize inbred lines. Genetics. 190: 1547-1562.
Corbi J., Dutheil J., Damerval C., Tenaillon M.I., Manicacci D. (2012). Accelerated evolution and coevolution drove the evolutionary history of AGPase subunits during Angiosperm radiation. Annals of Botany. 109: 693-708.
Tenaillon M.I., Manicacci D. (2011). Maize origins: an old question under the spotlights. Book chapter in Advances in Maize (Essential reviews in Experimental Biology). 3: 89-110.
Tenaillon M.I., Hufford, Gaut B.S., Ross-Ibarra J. (2011). Genome size and transposable element content as determined by high-thoughput sequencing in maize and Zea luxurians. Genome Biology and Evolution. 3: 219-229.
Tenaillon M.I., Charcosset A. (2011). A European perspective on maize history. Comptes rendus de l'Académie des sciences. 334: 221-228.
Corbi J., Debieu M., Rousselet A. Montalent P., Leguilloux M., Manicacci D., Tenaillon M.I. (2011). Contrasted patterns of selection since maize domestication on duplicated genes encoding a starch pathway enzyme. Theoretical and Applied Genetics. 122: 705-722.
Tenaillon M.I., Hollister J.D., Gaut B.S. (2010). A Triptych of the evolution of plant transposable elements. Trends in Plant Science. 15(8): 471-478.
Durand E., Tenaillon M.I., Ridel C., Coubriche D., Jamin P., Jouanne S., Charcosset A., Dillmann C. (2010). Standing variation and new mutations both contribute to a fast response to selection for flowering time in maize inbreds. BMC Evolutionary Biology. 10:2.
Parisod C., Salmon A., Zerjal T., Tenaillon M., Grandbastien M-A., Ainouche M. (2009). Rapid structural and epigenetic reorganization near transposable element in hybrid and allopolyploid genomes in Spartina. New Phytologist. 184(4):1003-1015.
Zerjal T., Joets J., Alix K., Grandbastien M-A., Tenaillon M.I. (2009). Contrasting evolutionary patterns and target specificities among three Tourist-like MITE families in the maize genome. Plant Molecular Biology. 71:99-114.
Legrand D., Tenaillon M.I., Matyot P., Gerlach J., Lachaise D., Cariou M-L. (2009). Species–wide genetic variation and demographic history of Drosophila sechellia, a species lacking population structure. Genetics. 182:1197-1206.
Ross-Ibarra J., Tenaillon M., Gaut B.S. (2009). Historical divergence and gene flow in the genus Zea. Genetics. 181:1399-1413.
Camus-Kulandaivelu L., Chevin L-M., Tollon C., Charcosset A., Manicacci D., Tenaillon M.I. (2008). Patterns of variation of the Tb1-D8 region shed light into early maize evolutionary history. Genetics. 180:1107-1121.
Tenaillon M.I. and
Thuillet A-C., Tenaillon M.I., Anderson L.K., Mitchell S.E., Kresovich S., Stack S.M., Gaut B.S. and Doebley J (2008). A weak effect of background selection on trinucleotide microsatellites in maize. Journal of Heredity. 99(1): 45-55.
Moeller D.A., Tenaillon M.I. and
Yamasaki M., Tenaillon M. I., Vroh Bi I., Schroeder S.G., Sanchez-Villeda H., Doebley J.F., Gaut B.S., and McMullen M.D. (2005). A large scale screen for artificial selection in maize identifies candidate agronomic loci for domestication and crop improvement. Plant Cell. 17(11): 2859-2872.
Tenaillon M. I., U'Ren J., Tenaillon O., and Gaut B.S. (2004). Selection versus demography: a multilocus investigation of the domestication process in maize. Molecular Biology and Evolution. 21(7): 1214-1225.
Tenaillon M. I., Sawkins M. C., Anderson L. K., Stack S. M., Doebley J., and Gaut B. S.(2002). Patterns of diversity and recombination along chromosome 1 of maize (Zea mays ssp. mays L.) . Genetics. 162: 1401-1413.
Whitt S. R., Wilson L. M., Tenaillon M. I., Gaut B. S., and Buckler E. S.4th. (2002). Genetic diversity and selection in the maize starch pathway. Proc. Natl. Acad. Sci. USA. 99: 12959-12962.
Tenaillon M. I., Sawkins M. C., Long A. D., Gaut R. L., Doebley J. F., and Gaut B. S. (2001). Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea mays ssp. mays L.). Proc. Natl. Acad. Sci. USA. 98: 9161-9166.
Gaut B. S., Le Thierry d'Ennequin M., Peek A. S., and Sawkins M. C. (2000). Maize as a model for the evolution of plant nuclear genome. Proc. Natl. Acad. Sci. USA. 97: 7008-7015.
Le Thierry d'Ennequin M., Panaud O., and Sarr A. (2000). Assessment of genetic relationships between Setaria italica and its wild progenitor, S. viridis using AFLP markers to elucidate the origin of foxtail millet domestication. Theoretical and Applied Genetics. 100: 1061-1066.
Le Thierry d'Ennequin M., Toupance B., Robert T., Godelle B., and Gouyon P.-H. (1999). Plant domestication: a model for studying the evolution of linkage. Journal of Evolutionary Biology. 12 : 1138-1147.
Le Thierry d'Ennequin M., Panaud O., Brown S., Siljak-Yakovlev S., and Sarr A. (1998). First evaluation of nuclear DNA content by flow cytometry in Setaria gene pool . Journal of Heredity. 89: 556-559.
Le Thierry d'Ennequin M., Panaud O., Robert T., and Ricroch A. ( 1997). Assessment of genetic relationships among sexual and asexual forms of Allium cepa using morphological traits and RAPD markers. Heredity. 78: 403-409.