maud
holding teosintes
 
Maud Tenaillon 
Evolutionary genetics
    Genetic diversity and plant domestication   

    CNRS researcher, Dept. Plant Genetics
                           Ferme du Moulon

    Contact information
    UMR de Génétique Végétale
    Ferme du Moulon
    91190 Gif-sur-Yvette    
    France
    

   phone: + 33 (0) 69 33 23 34
    fax: + 33 (0) 1 69 33 23 40
    email: tenaillon@moulon.inra.fr

 
Research    
Pictures    


                         
 Research Interest

My research focus on understanding how the evolutionary forces shape the genetic variation of plant genomes in relation with adaptation. I have a particular interest for plant domestication as a model of adaptation. At the genome level, domestication involved a loss of diversity resulting from both a bottleneck and selection at target genes. I've been working on depicting this process in a selfer plant, the foxtail millet, adressing questions such as: What are the genetic basis of domestication? Is there an influence of the breeding system on the organization of domesticated genes? I am currently focusing on maize as a model species. I investigated the influence of recombination and selection in shaping patterns of both nucleotide  and  microsatellite diversity in this species. I worked both: at a small scale in between two loci, one has been subjected to strong selection during domestication and the other has been involved in climate adaptation; and at a broader scale considering multiple loci. In particular, I developped a multilocus model to investigate the impact of demography (domestication bottleneck) on diversity and long distance linkage disequilibrium. This model was applied in a large dataset to identify loci under selection in maize. I am currently developping two main projects. One project examines the evolution in Angiosperms of a multigene family encoding a key enzyme of the starch pathway and aims at characterizing the forces that primarly determine the fate of duplicated genes. Because increase in starch content is considered as a major domestication trait, I also focus on the expression and patterns of variability of these duplicates in maize and its wild progenitor. The second project aims at investigating the role of transposable elements (TEs) in the domestication process. Using markers that reveal the polymorphism of insertion of TEs, I want to unravel the demographic history of maize (landraces) and wild relatives populations (ssp. parviglumis and mexicana) and to identify insertions that may have contributed to local adaptation. Current collaborative projects concern the evolution of genome size in the genus Zea (collaboration with B. Gaut and J. Ross-Ibarra) and the contribution of new (epi)mutations in a divergent selection experiment for flowering time in maize (collaboration with C. Dillmann, A. Charcosset, E. Durand). 

Current collaborators on those projects include
Master student: O. Nougué
 Former postdoc: T. Zerjal
PhD student: E. Durand (cosupervision with C. Dillmann and A. Charcosset)
Members of the GEAR research group D. Manicacci, K. Alix-Jenczewski, C. Vitte, C. Damerval
Members of the department C. Dillmann, S. Nicolas and A. Charcosset
Other French research groups M-A. Grandbastien and C. Mhiri from INRA Versailles
Abroad researchers: B. Gaut (UC Irvine, USA), J. Ross-Ibarra (UC Davis, USA), M. Hufford (UC Davis, USA), L. Eguiarte (UNAM, Mexico)

Past collaborators
Former PhD student L. Camus-Kulandaivelu, J. Corbi
O. Tenaillon from INSERM U722
D. Legrand and M-L Cariou from LEGS (France)
F. Austerlitz and L-M Chevin from ESE (France)
A-C Thuillet from IRD (France)
P. Tiffin from Univ. of Minnesota (USA)

Positions and Education

CNRS researcher (CR1), Department of Plant Genetics, Ferme du Moulon (France), 2002-present
Awarded by the CNRS bronze medal in 2011
Visiting researcher in the Gaut lab at UC Irvine, 2009-2011
HDR defended in April 2009 (University of Orsay)
Postdoctoral fellow (NSF) in the Gaut lab , Department of Ecology and Evolutionary Biology, UC Irvine (USA), 1999-2002
PhD student, Department of Evolution and Systematic , University of Orsay (France), 1995-1999


 Publications

icone Corbi J., Dutheil J., Damerval C., Tenaillon M.I., Manicacci D. (in press). Accelerated evolution and coevolution drove the evolutionary history of AGPase subunits during Angiosperm radiation. Annals of Botany.
icone Tenaillon M.I., Manicacci D. (2011). Maize origins: an old question under the spotlights. Book chapter in Advances in Maize (Essential reviews in Experimental Biology). 3: 89-110.

icone Tenaillon M.I., Hufford, Gaut B.S., Ross-Ibarra J. (2011). Genome size and transposable element content as determined by high-thoughput sequencing in maize and Zea luxurians. Genome Biology and Evolution. 3: 219-229.
icone Tenaillon M.I., Charcosset A. (2011). A European perspective on maize history. Comptes rendus de l'Académie des sciences. 334: 221-228.
icone Corbi J., Debieu M., Rousselet A. Montalent P., Leguilloux M., Manicacci D., Tenaillon M.I. (2011). Contrasted patterns of selection since maize domestication on duplicated genes encoding a starch pathway enzyme. Theoretical and Applied Genetics. 122: 705-722.
icone Tenaillon M.I., Hollister J.D., Gaut B.S. (2010). A Triptych of the evolution of plant transposable elements. Trends in Plant Science. 15(8): 471-478.
icone Durand E., Tenaillon M.I., Ridel C., Coubriche D., Jamin P., Jouanne S., Charcosset A., Dillmann C. (2010). Standing variation and new mutations both contribute to a fast response to selection for flowering time in maize inbreds. BMC Evolutionary Biology. 10:2.
icone Parisod C., Salmon A., Zerjal T.,  Tenaillon M., Grandbastien M-A., Ainouche M. (2009). Rapid structural and epigenetic reorganization near transposable element in hybrid and allopolyploid genomes in Spartina. New Phytologist. 184(4):1003-1015.
icone Zerjal T., Joets J., Alix K., Grandbastien M-A., Tenaillon M.I. (2009). Contrasting evolutionary patterns and target specificities among three Tourist-like MITE families in the maize genome. Plant Molecular Biology. 71:99-114.
icone Legrand D., Tenaillon M.I., Matyot P., Gerlach J., Lachaise D., Cariou M-L. (2009). Species–wide genetic variation and demographic history of Drosophila sechellia, a species lacking population structure. Genetics. 182:1197-1206.
icone Ross-Ibarra J., Tenaillon M., Gaut B.S. (2009). Historical divergence and gene flow in the genus Zea. Genetics. 181:1399-1413.
icone Camus-Kulandaivelu L., Chevin L-M., Tollon C., Charcosset  A., Manicacci D., Tenaillon M.I. (2008). Patterns of variation of the Tb1-D8 region shed light into early maize evolutionary history. Genetics. 180:1107-1121.
icone Tenaillon M.I. and Tiffin P.L. (2008). The quest for adaptive evolution: a theoretical challenge in a maze of data. Curr. Opin. Plant Biol. 11(2):110-115.
icone Tenaillon M.I., Austerlitz F. and Tenaillon O. (2008). Apparent mutational hotspots and long distance LD resulting from a bottleneck. J. Evol. Biol. 21(2):541-550.
icone Thuillet A-C., Tenaillon M.I., Anderson L.K., Mitchell S.E., Kresovich S., Stack S.M., Gaut B.S. and Doebley J (2008). A weak effect of background selection on trinucleotide microsatellites in maize. J. of Heredity. 99(1): 45-55.
icone Moeller D.A., Tenaillon M.I. and Tiffin P. (2007). Population structure and its effects on patterns of nucleotide polymorphism in the teosinte (Zea mays ssp. parviglumis). Genetics 176(3):1799-1809.
icone Yamasaki M., Tenaillon M. I., Vroh Bi I., Schroeder S.G., Sanchez-Villeda H., Doebley J.F., Gaut B.S., and McMullen M.D. (2005). A large scale screen for artificial selection in maize identifies candidate agronomic loci for domestication and crop improvement. Plant Cell 17(11):2859-2872.
pdficone Tenaillon M. I., U'Ren J., Tenaillon O., and Gaut B.S. (2004). Selection versus demography: a multilocus investigation of the domestication process in maize. Mol. Biol. Evol. 21(7): 1214-1225.
icone Tenaillon M. I., Sawkins M. C., Anderson L. K., Stack S. M., Doebley   J., and Gaut B. S.(2002). Patterns of diversity and recombination along chromosome 1 of maize (Zea mays ssp. mays L.) . Genetics. 162: 1401-1413.
icone  Whitt S. R., Wilson L. M., Tenaillon M. I., Gaut B. S., and Buckler E. S.4th. (2002). Genetic diversity and selection in the maize starch pathway. Proc. Natl. Acad. Sci. U.S.A. 99: 12959-12962.
icone Tenaillon M. I., Sawkins M. C., Long A. D., Gaut R. L., Doebley J. F., and Gaut B. S. (2001). Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea mays ssp. mays L.). Proc. Natl. Acad. Sci. U. S. A. 98: 9161-9166.
icone  Gaut B. S., Le Thierry d'Ennequin M., Peek A. S., and Sawkins M. C. (2000). Maize as a model for the evolution of plant nuclear genome. Proc. Natl. Acad. Sci. U. S. A. 97: 7008-7015.
icone  Le Thierry d'Ennequin M., Panaud O., and Sarr A. (2000). Assessment of genetic relationships between Setaria italica and its wild progenitor, S. viridis using AFLP markers to elucidate the origin of foxtail millet domestication. Theor. and Appl. Genet. 100: 1061-1066.
iconeLe Thierry d'Ennequin M., Toupance B., Robert T., Godelle B., and Gouyon P.-H. (1999).  Plant domestication: a model for  studying the evolution of linkage. Journal of Evolutionary Biology 12 : 1138-1147.
icone   Le Thierry d'Ennequin M., Panaud O., Brown S., Siljak-Yakovlev S., and Sarr A. (1998).  First evaluation of nuclear DNA content by flow cytometry in Setaria gene pool . Journal of Heredity 89:  556-559.
icone  Le Thierry d'Ennequin M., Panaud O., Robert T., and Ricroch A. ( 1997). Assessment of genetic relationships among sexual and asexual forms of Allium cepa using morphological traits and RAPD markers. Heredity 78: 403-409.


Family pictures
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image3 katie
    felix
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